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1.What is the (S)-(+)-Ibuprofen ?
Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, μM, respectively). It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form. (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 μM, respectively). However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 μM). A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.
Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, μM, respectively). It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form. (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 μM, respectively). However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 μM). A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.
2.What is the CAS number for (S)-(+)-Ibuprofen ?
The CAS number of (S)-(+)-Ibuprofen is 51146-56-6.
More information of (S)-(+)-Ibuprofen 51146-56-6 are:
|
CAS?Number |
51146-56-6 |
|
Density |
1.029 g/cm3 |
|
Melting Point |
49-53 °C(lit.) |
|
Boiling Point |
319.6 °C at 760 mmHg |
|
Flash Point |
216.7 °C |
|
Vapor Pressure |
0.000139mmHg at 25°C |
|
Refractive Index |
59 ° (C=2, EtOH) |
|
HS CODE |
29163990 |
|
PSA |
37.30000 |
|
LogP |
3.07320 |
|
Pka |
4.41±0.10(Predicted) |
3.What is the molecular formula of (S)-(+)-Ibuprofen ?
The chemical formula of?(S)-(+)-Ibuprofen is C13H18O2 which containing 13 Carbon atoms,18 Hydrogen atoms and 2 Oxygen atoms,and the molecular weight, and the molecular weight of (S)-(+)-Ibuprofen is 206.285
4.What is (S)-(+)-Ibuprofen(51146-56-6)used for?
Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, μM, respectively). It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form. (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 μM, respectively). However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 μM). A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.
InChI:InChI=1/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1
Relevant articles related to (S)-(+)-Ibuprofen:
|
Article |
Source |
|
High pressure CO2-controlled reactors: Enzymatic chiral resolution in emulsions |
Shang, Wenting,Zhang, Xiaogang,Yang, Xiaoxi,Zhang, Shujuan , p. 24083 - 24088 (2014) |
|
Enzymatic hydrolytic resolution of racemic ibuprofen ethyl ester using an ionic liquid as cosolvent |
Wei, Tao,Yang, Kunpeng,Bai, Bing,Zang, Jie,Yu, Xuan,Mao, Duobin , (2016) |
5.Factory Export Top Purity (S)-(+)-Ibuprofen 51146-56-6 In Stock
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