(S)-(+)-Ibuprofen

  • CAS No.: 51146-56-6
  • Purity: 99%
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1.What is the (S)-(+)-Ibuprofen ?

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, μM, respectively). It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form. (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 μM, respectively). However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 μM). A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, μM, respectively). It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form. (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 μM, respectively). However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 μM). A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.

2.What is the CAS number for (S)-(+)-Ibuprofen ?

The CAS number of (S)-(+)-Ibuprofen is 51146-56-6.

More information of (S)-(+)-Ibuprofen 51146-56-6 are:

CAS?Number

51146-56-6

Density

1.029 g/cm3

Melting Point

49-53 °C(lit.)

Boiling Point

319.6 °C at 760 mmHg

Flash Point

216.7 °C

Vapor Pressure

0.000139mmHg at 25°C

Refractive Index

59 ° (C=2, EtOH)

HS CODE

29163990

PSA

37.30000

LogP

3.07320

Pka

4.41±0.10(Predicted)

3.What is the molecular formula of (S)-(+)-Ibuprofen ?

The chemical formula of?(S)-(+)-Ibuprofen is C13H18O2 which containing 13 Carbon atoms,18 Hydrogen atoms and 2 Oxygen atoms,and the molecular weight, and the molecular weight of (S)-(+)-Ibuprofen is 206.285

4.What is (S)-(+)-Ibuprofen(51146-56-6)used for?

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, μM, respectively). It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form. (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 μM, respectively). However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 μM). A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.

InChI:InChI=1/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1

Relevant articles related to (S)-(+)-Ibuprofen:

Article

Source

High pressure CO2-controlled reactors: Enzymatic chiral resolution in emulsions

Shang, Wenting,Zhang, Xiaogang,Yang, Xiaoxi,Zhang, Shujuan

, p. 24083 - 24088 (2014)

Enzymatic hydrolytic resolution of racemic ibuprofen ethyl ester using an ionic liquid as cosolvent

Wei, Tao,Yang, Kunpeng,Bai, Bing,Zang, Jie,Yu, Xuan,Mao, Duobin

, (2016)

5.Factory Export Top Purity (S)-(+)-Ibuprofen 51146-56-6 In Stock

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